Courtesy of LKCMedicine Assistant Professor Navin Kumar Verma
In this picture, a human T lymphocyte was stimulated to migrate in a laboratory setting, mimicking a tissue site of inflammation. The cell was immunostained for the cytoskeletal proteins α-tubulin (green) and actin (purple) in addition to a signalling protein (red) and nucleus (blue). Notably, migrating T lymphocytes display two opposite cell edges, a leading edge and trailing edge. By studying their behaviour, Assistant Professor of Immunology & Cell Biology Navin Kumar Verma hopes to find new ways of treating immune-mediated inflammatory disorders, such as rheumatoid arthritis and psoriasis.